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Index > Protein center > Notch1(Gene name) > Rat
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  • Notch1 (Gene name),
  • Neurogenic locus notch homolog protein 1 (Protein name ),  NOTC1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Notch1;
    Protein name:
    Neurogenic locus notch homolog protein 1(Notch 1);
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.
    Function:
    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.
    Subcellular Location:
    Notch 1 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.
    Protein Attributes:
    Sequence length:
    2531
    Sequence:
    50:
    MPRLLAPLLC | LTLLPALAAR | GLRCSQPSGT | CLNGGRCEVA | NGTEACVCSG | 
    100:
    AFVGQRCQDP | SPCLSTPCKN | AGTCYVVDHG | GIVDYACSCP | LGFSGPLCLT | 
    150:
    PLANACLANP | CRNGGTCDLL | TLTEYKCRCP | PGWSGKSCQQ | ADPCASNPCA | 
    200:
    NGGQCLPFES | SYICGCPPGF | HGPTCRQDVN | ECSQNPGLCR | HGGTCHNEIG | 
    250:
    SYRCACRATH | TGPHCELPYV | PCSPSPCQNG | GTCRPTGDTT | HECACLPGFA | 
    300:
    GQNCEENVDD | CPGNNCKNGG | ACVDGVNTYN | CRCPPEWTGQ | YCTEDVDECQ | 
    350:
    LMPNACQNAG | TCHNSHGGYN | CVCVNGWTGE | DCSDNIDDCA | SAACFQGATC | 
    400:
    HDRVASFYCE | CPHGRTGLLC | HLNDACISNP | CNEGSNCDTN | PVNGKAICTC | 
    450:
    PRGYTGPACS | QDVDECALGA | NPCEHAGKCL | NTLGSFECQC | LQGYTGPRCE | 
    500:
    IDVNECISNP | CQNDATCLDQ | IGEFQCICMP | GYEGVYCEIN | TDECASSPCL | 
    550:
    HNGRCVDKIN | EFLCQCPKGF | SGHLCQYDVD | ECASTPCKNG | AKCLDGPNTY | 
    600:
    TCVCTEGYTG | THCEVDIDEC | DPDPCHIGLC | KDGVATFTCL | CQPGYTGHHC | 
    650:
    ETNINECHSQ | PCRHGGTCQD | RDNYYLCLCL | KGTTGPNCEI | NLDDCASNPC | 
    700:
    DSGTCLDKID | GYECACEPGY | TGSMCNVNID | ECAGSPCHNG | GTCEDGIAGF | 
    750:
    TCRCPEGYHD | PTCLSEVNEC | NSNPCIHGAC | RDGLNGYKCD | CAPGWSGTNC | 
    800:
    DINNNECESN | PCVNGGTCKD | MTSGYVCTCR | EGFSGPNCQT | NINECASNPC | 
    850:
    LNQGTCIDDV | AGYKCNCPLP | YTGATCEVVL | APCATSPCKN | SGVCKESEDY | 
    900:
    ESFSCVCPTG | WQGQTCEIDI | NECVKSPCRH | GASCQNTNGS | YRCLCQAGYT | 
    950:
    GRNCESDIDD | CRPNPCHNGG | SCTDGVNAAF | CDCLPGFQGA | FCEEDINECA | 
    1000:
    TNPCQNGANC | TDCVDSYTCT | CPTGFNGIHC | ENNTPDCTES | SCFNGGTCVD | 
    1050:
    GINSFTCLCP | PGFTGSYCQY | DVNECDSRPC | LHGGTCQDSY | GTYKCTCPQG | 
    1100:
    YTGLNCQNLV | RWCDSAPCKN | GGKCWQTNTQ | YHCECRSGWT | GFNCDVLSVS | 
    1150:
    CEVAAQKRGI | DVTLLCQHGG | LCVDEEDKHY | CHCQAGYTGS | YCEDEVDECS | 
    1200:
    PNPCQNGATC | TDYLGGFSCK | CVAGYHGSNC | SEEINECLSQ | PCQNGGTCID | 
    1250:
    LTNTYKCSCP | RGTQGVHCEI | NVDDCHPPLD | PASRSPKCFN | NGTCVDQVGG | 
    1300:
    YTCTCPPGFV | GERCEGDVNE | CLSNPCDPRG | TQNCVQRVND | FHCECRAGHT | 
    1350:
    GRRCESVING | CRGKPCRNGG | VCAVASNTAR | GFICRCPARF | EGATCENDAR | 
    1400:
    TCGSLRCLNG | GTCISGPRSP | TCLCLGSFTG | PECQFPASSP | CVGSNPCYNQ | 
    1450:
    GTCEPTSESP | FYRCLCPAKF | NGLLCHILDY | SFTGAAGRDI | PPPQIEEACE | 
    1500:
    LPECQEDAGN | KVCNLQCNNH | ACGWDGGDCS | LNFNDPWKNC | TQSLQCWKYF | 
    1550:
    SDGHCDSQCN | SAGCLFDGFD | CQLTEGQCNP | LYDQYCKDHF | SDGHCDQGCN | 
    1600:
    SAECEWDGLD | CAEHVPERLA | AGTLVLVVLL | PPDQLRNNSF | HFLRDVSHVL | 
    1650:
    HTNVVFKRDA | QGQQMIFPYY | GREEELRKHP | IKRSAVGWAT | TSLLPGTNGG | 
    1700:
    RQRRELDPMD | IHGSIVYLEI | DNRQCVQSSS | QCFQSATDVA | AFLGALASLG | 
    1750:
    SLNIPYKIEA | VKSETVEPPL | PSQLHLMYVA | AAAFVLLFFV | GCGVLLSRKR | 
    1800:
    RRQHGQLWFP | EGFKVSEASK | KKRREPLGED | SVGLKPLKNA | SDGALMDDNQ | 
    1850:
    NEWGDEDLET | KKFRFEEPVV | LPDLDDQTDH | RQWTQQHLDA | ADLRVSAMAP | 
    1900:
    TPPQGEVDAD | CMDVNVRGPD | GFTPLMIASC | SGGGLETGNS | EEEEDAPAVI | 
    1950:
    SDFIYQGASL | HNQTDRTGET | ALHLAARYSR | SDAAKRLLEA | SADANIQDNM | 
    2000:
    GRTPLHAAVS | ADAQGVFQIL | LRNRATDLDA | RMHDGTTPLI | LAARLAVEGM | 
    2050:
    LEDLINSHAD | VNAVDDLGKS | ALHWAAAVNN | VDAAVVLLKN | GANKDMQNNK | 
    2100:
    EETPLFLAAR | EGSYETAKVL | LDHFANRDIT | DHMDRLPRDI | AQERMHHDIV | 
    2150:
    RLLDEYNLVR | SPQLHGTALG | GTPTLSPTLC | SPNGYLGNLK | SATQGKKARK | 
    2200:
    PSTKGLACSS | KEAKDLKARR | KKSQDGKGCL | LDSSSMLSPV | DSLESPHGYL | 
    2250:
    SDVASPPLLP | SPFQQSPSMP | LSHLPGMPDT | HLGISHLNVA | AKPEMAALAG | 
    2300:
    GSRLAFEPPP | PRLSHLPVAS | SASTVLSTNG | TGAMNFTVGA | PASLNGQCEW | 
    2350:
    LPRLQNGMVP | SQYNPLRPGV | TPGTLSTQAA | GLQHGMMGPI | HSSLSTNTLS | 
    2400:
    PIIYQGLPNT | RLATQPHLVQ | TQQVQPQNLQ | IQPQNLQPPS | QPHLSVSSAA | 
    2450:
    NGHLGRSFLS | GEPSQADVQP | LGPSSLPVHT | ILPQESQALP | TSLPSSMVPP | 
    2500:
    MTTTQFLTPP | SQHSYSSSPV | DNTPSHQLQV | PEHPFLTPSP | ESPDQWSSSS | 
    2531:
    RHSNISDWSE | GISSPPTSMP | SQITHIPEAF | K
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Notch 1
    Cat.:
    E0501h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Notch 1
    Cat.:
    E0501r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Notch 1
    Cat.:
    E0501m
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    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Notch 1
    Cat.:
    U0501m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Notch 1
    Cat.:
    U0501h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Notch 1
    Cat.:
    U0501r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Notch 1
    Cat.:
    P0501Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Notch 1
    Cat.:
    P0501Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Notch 1
    Cat.:
    P0501Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Notch 1
    Monoclonal Antibody for Rat Notch 1
    Monoclonal Antibody for Rat Notch 1
    Protein for Rat Notch 1
    Protein for Rat Notch 1
    Protein for Rat Notch 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A homolog of Drosophila Notch expressed during mammalian development."
      Weinmaster G. , Roberts V.J. , Lemke G.
      Development113:199-205(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Schwann cell.
    2. 2.
      Weinmaster G.
      Submitted (1998-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 1652-1653
    3. 3.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate."
      Tanigaki K. , Nogaki F. , Takahashi J. , Tashiro K. , Kurooka H. , Honjo T.
      Neuron29:45-55(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 7.
      "Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development."
      Irvin D.K. , Zurcher S.D. , Nguyen T. , Weinmaster G. , Kornblum H.I.
      J. Comp. Neurol.436:167-181(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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